A novel immunomodulatory peptide that can be used for treatment of infectious diseases, Cardiovascular Ischemia/Reperfusion injury, Acute Kidney Injury and Multiple Myeloma

Recherche de partenaires
Type de partenaire: 
Entreprise
Type de recherche: 
BBS
Référence de l’annonce: 
12 IL 80EP 3O1C
An Israeli clinical stage biotechnology company is looking for a partner to collaborate on developing its lead compound, a short peptide antagonist of CD28, for treatment of immune related diseases. The company is seeking to collaborate with service providers, academic researchers and clinical investigators in the fields of drug development (preclinical and clinical) in the area of Cardiovascular Ischemia reperfusion injury and multiple myeloma.

 

Caractéristiques techniques ou commerciales attendues : 
The Israeli company is a clinical stage biotechnology company that develops therapeutics for diseases mediated by an excessive inflammatory response. The company focuses on novel modulators of the immune response that act broadly to attenuate excessive cytokine responses underlying disease, with therapeutic applications ranging from infectious to inflammatory/autoimmune diseases. These applications represent areas with major unmet medical need.

The Israeli company discovered a novel mechanism underlying harmful inflammatory cytokine responses, allowing the company to modulate this response with rationally designed short peptides. These proprietary peptides act as antagonists that inhibit immune over-reaction early in the inflammatory cascade while preserving normal immune responses.

The company is looking for technical collaborations in the field of In-vivo testing and clinical trials of its lead compound in the areas of Cardiac Ischemia – Reperfusion injury and Multiple Myeloma.

Technical Specifications / Specific technical requirements of the request
The selected partner should be either an academic lab, contract research organization – CRO or a research lab with the capacity of holding a comprehensive research and development plan by either cell based and in-vitro assays, or in-vivo animal disease models. The capacity should be such that the company can rely on its expertise in order to establish either a significant progress in understanding the compound’s Mechanism of Action and establish basic Proof of Concept animal models for diseases and indications mentioned above.